Trem2 uniprot. (AF1828) TREM 2019-03-25

Trem2 uniprot Rating: 8,9/10 1366 reviews

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trem2 uniprot

Engagement of these receptors can also prime myeloid cells to respond to other stimuli. UniProt Summary: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. References Product Information Format Purified Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating e. Initiator caspases including 8, 9, 10, and 12 are closely coupled to proapoptotic signals. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies. Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Polyclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Creative Biolabs Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Other Other Other Other Other Other Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant Recombinant United States Biological Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal.

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Human TREM2 / TREM

trem2 uniprot

Molecular Mass: The recombinant mouse Trem2 consists 389 amino acids and predicts a molecular mass of 43. This is contrary to the prevailing idea that the soluble fragment functions primarily as a decoy receptor, hoarding available ligands away from its parent. The assigned to this protein are shown if expanding the data in the protein class column. Target band size appears larger than the calculated moleuclar weights of 25. Arginase-1 catalyzes the final step of the urea cycle converting L-arginine to L-ornithine and urea 5.

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TREM2 / TREM

trem2 uniprot

Research and Reports in Biochemistry. To access sample data, click on tissue name or bar. The Journal of Infectious Diseases. Multiple isoforms of hemoglobin exist, which vary in relative abundance depending on developmental stage. Storage: Store it under sterile conditions at -20ºC~-70ºC.

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Tissue expression of TREM2

trem2 uniprot

MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. For example the 'T' icon T represents expression tags that have been added to the sequence. Minor changes may occur to the Range, Sensitivity, and Precision. Erratum in: Am J Hum Genet. Each antibody in the panel has been validated for this approach. The Journal of Experimental Medicine. Activated caspase-8 cleaves and activates downstream effector caspases, such as caspase-1, -3, -6, and -7.

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TREM2

trem2 uniprot

An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Mutations that alter the structure or abundance of specific globin subunits can result in pathological conditions known as hemoglobinopathies 4. These cells are involved in bone remodeling, which is a normal process that replaces old bone tissue with new bone. The 'E' icon E represents an engineered mutation. Hemoglobin also facilitates metabolic waste removal by assisting in the transport of carbon dioxide from tissues back to the respiratory organs 1. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped. Centrifuge the vial at 4ºC before opening to recover the entire contents.

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CB1 Receptor (D5N5C) Rabbit mAb, UniProt ID P21554 #93815 to DYKDDDDK Tag (D6W5B) Rabbit mAb (Sepharose® Bead Conjugate) #70569 from Cell Signaling Technology

trem2 uniprot

Associates with on dendritic cells to mediate up-regulation of chemokine receptor and dendritic cell maturation and survival PubMed:11602640. Alternative splicing results in multiple transcript variants encoding different isoforms. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. It has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail. Mouse-over function shows protein score for analyzed cell types in a selected tissue. Öhrfelt A, Axelsson M, Malmeström C, Novakova L, Heslegrave A, Blennow K, Lycke J, Zetterberg H.

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(AF1828) TREM

trem2 uniprot

The primary function of hemoglobin is to transport oxygen from the external environment to the body tissues. More information can be found in. The length of the protein amino acid residues according to Ensembl , molecular mass kDalton , predicted signal peptide according to a majority of the signal peptide predictors , , and and the number of predicted transmembrane region s according to are also reported. It is found on the plasma membrane, as well as endosomal and lysosomal membranes 1-3. I guess the authors will follow this up soon. Validation Track For more details on the Validation Track Structure Summary Page only see. Proceedings of the National Academy of Sciences of the United States of America.

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anti

trem2 uniprot

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0. More information can be found in. Make a Comment To make a comment you must or. Common purple and unique grey regions between different splice variants of the gene are also displayed , and at the bottom of the protein view is the protein scale. Forms a receptor signaling complex with and triggers activation of the immune responses in macrophages and dendritic cells PubMed:10799849. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards.

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Human TREM2 / TREM

trem2 uniprot

Any sequences containing the modified nucleotide will be enriched by the immunoselection process. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Heslegrave A, Heywood W, Paterson R, Magdalinou N, Svensson J, Johansson P, Öhrfelt A, Blennow K, Hardy J, Schott J, Mills K, Zetterberg H. She believes the soluble fragment may be crucial for mounting acute responses to injuries or infections that occur throughout life. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. It is found on the plasma membrane, as well as endosomal and lysosomal membranes 1-3.

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Antibodypedia

trem2 uniprot

The curve in blue displays the predicted antigenicity i. For more information about the meaning and exact position of a sequence modification, move the cursor over the icon. Others have shown the particular variants tested, R47H and R62H, as either Trem2-Fc proteins or expressed within reporter cell lines to impede Trem2 recognition of apolipoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. Brain Protein expression data is shown for each of the 44 tissues.

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